Early-Life Risk Factors for Childhood Wheeze Phenotypes in a High-Risk Birth Cohort
نویسنده
چکیده
METHODS. The subjects (85% polysensitized, 25% with asthma) were randomized 1:1 to receive once-daily MK7243 (2800 BAU P pratense) or placebo. The first dose was given at the investigator’s office; subsequent doses were self-administered at home. The primary end point was total combined score (TCS) (composed of rhinoconjunctivitis daily symptom score plus daily medication score) over the entire grass pollen season. Key secondary end points included entire-season daily symptom score, daily medication score, peak-season TCS, and rhinoconjunctivitis quality-of-life questionnaire scores. Safety outcomes included adverse events (AEs).
منابع مشابه
Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort.
OBJECTIVE To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors. STUDY DESIGN Current wheeze was recorded 23 times up to age 7 years in a birth cohort at high risk for allergy (n = 620). Latent class analysis of wheeze responses identified 5 classes. Multinomial logistic regression estimated associations of probability-weighted wheezing classes with ear...
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